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Regina Stevens-Truss, Ph.D.

Abridged Curriculum Vitae


        Education & Training

    1999-2000     Lecturer, Medicinal Chemistry, University of Michigan  

    1997-1999    Merck•UNCF Fellowship in Medicinal Chemistry, University of Michigan

1993-1997    Research Fellowship in Medicinal Chemistry, University of Michigan

1993          Ph.D. in Medicinal Chemistry, University of Toledo, College of Pharmacy
                       Thesis:  Cobra Venom Cytotoxins: Structure / Function Determination                 

    1983          B.A. Rutgers University
                           Major:  Biology
                           Minors:  Chemistry & Spanish


    Professional Titles


    7/02-Present    Roger F. & Harriet G. Varney Assistant Professor of Chemistry
                            Kalamazoo College
    1/01-Present    Director of The Art & Science of Medicine, an HHMI Program
                            Kalamazoo College



    Professional Membership


    8/02-present     Member, The Protein Society
    1/00-present    Member, American Societies of Biochemists and Molecular Biologists
    1/00-present    Member, American Chemical Society


    Recent Invited Lectures


    “"Studying Nitric Oxide Synthase in an Effort at Designing Isoform Specific Inhibitors". University of Michigan, October, 2003.

    “"Understanding Nitric Oxide Synthase as a tool in drug design". Lake Forrest College, October, 2003.

“"Incorporating Service-Learning Into the Major". Pew Midstates Science and Mathematics Consortium, Spring Mini-Symposium: Attracting and Retaining Majors, March, 2003..

“"The Science of Chemical and Biological Warfare".  Kalamazoo College, Liberal Arts Colloquium, February, 2002.

    “"Cytochrome P450 Enzymes:  Role in Cancer and Neurodegenerative Diseases".  Kalamazoo College, Faculty Seminar, February, 2002.

    “"Confronting Terrorism:  Facts and Myths about Anthrax".  Kalamazoo College, Faculty Public Forum, November, 2001.

    “"Nitric Oxide Synthase & Alzheimers Disease".  Calvin College, October, 2001.

    “"Feeding Hungry Children the ABCs of Science".  Regional ACS meeting, Grand Rapids, MI, June, 2001.

    “"Nitric Oxide Synthase:  The Bad, The Ugly, The Good".  University of Toledo, March 2001.


    Publications

    • Select Peer Reviewed(Undergraduate Student Contributors are italized)

    Gribovskaja, I., Brownlow, K. C., Dennis, S. J., Rosko, A. J., Marletta, M., and Stevens-Truss, R. Calcium Binding Sites of Calmodulin and Electron Transfer by Inducible Nitric Oxide Synthase. Submitted to Biochemistry, September, 2004.


    Stevens-Truss, R.
    , Brownlow, K. C., Marletta, M. A. and Michel, T. Inactivation of Nitric Oxide Synthase by Caveolin. In Preparation, for Submission to Archives of Biochemistry & Biophysics, December, 2004.

    Esson, J., Thomas, A., and Stevens-Truss, R. Service-Learning in Introductory Chemistry: Supplementing Chemistry Curriculum in Elementary Schools. Provisionally accepted by the Journal of Chemical Education, initially submitted June 2003 (revisions submitted January, 2004).

    Furge, L. L, Fields, P. R., Goode, W. E., Konwinski, R. R., Tressler, M. C., and Stevens-Truss, R. Oltipraz Inhibits Inducible Nitric Oxide Synthase in vitro and Inhibits Nitric Oxide Production in Activated Microglial Cells. Archives of Biochemistry & Biophysics (2004) 424: 163-170.

    Hinman, C. L., Stevens-Truss, R., Schwarz, C. J., and Hudson, R. A. Sequence Determinants of Modified Cobra Venom Neurotoxin Which Induce Immune Resistance to Experimental Allergic Encephalomyelitis: Molecular Mechanisms for Immunological Actions. Immonopharmacology and Immunotoxicology (1999) 21 (3):483-506.

    Hinman, C. L. and Stevens-Truss, R. In-Line Affinity Chromatographic Removal of Specific Antibodies from Rabbits with Experimental Myasthenia Gravis as a Prelude to Immunotherapy. Immonopharmacology and Immunotoxicology (1998) 20 (2):233-249.

    Stevens-Truss, R., Beckingham, K. and Marletta, M. A.  Calcium Binding Sites of Calmodulin and Electron Transfer by Neuronal Nitric Oxide Synthase.  Biochemistry (1997) 36 (40): 12337-12345.

    Stevens-Truss, R. and Hinman, C. L.  Activities of Cobra Venom Cytotoxins toward Heart and Leukemic T cells Depend on Localized Amino Acid Differences.  Toxicon (1997) 35 (5):659-669.

    Stevens-Truss, R. and Hinman, C. L.  Chemical Modification of Methionines in Cobra Venom Cytotoxin Differentiates Between Lytic and Binding Domains.  Toxicology and Applied Pharmacology (1996) 139 (2):234-242.

    Stevens-Truss, R. and Marletta, M. A.  Interaction of Calmodulin with the Inducible Murine Macrophage Nitric Oxide Synthase.  Biochemistry (1995) 34 (48):15638-15645.

    • Recent Meeting Abstracts with Undergraduate Student Contributors (italized)

    Rosko, A. J., Winter, M. B., and Stevens-Truss, R. "Mapping the Interactions of Neuronal Nitric Oxide Synthase and Calmodulin by Limited Proteolysis Followed by MALDI-TOF-TOF Mass Spectrometry." 36th Great Lakes Regional Meeting of the American Chemical Society, Peoria, IL, October, 2004. (Accepted for poster presentation)

    Sherman, R. F. and Stevens-Truss, R. "Analysis of the BV2 Proteome in Response to Select Cell Activators by 2D-Gel Electrophoresis and MALDI-TOF-TOF Mass Spectrometry." 36th Great Lakes Regional Meeting of the American Chemical Society, Peoria, IL, October, 2004. (Accepted for poster presentation)

    Furge, L. L., Fields, P. R., Goode, W. E., Tressler, M. C., and Stevens-Truss, R. "Inhibition of Inducible Nitric Oxide Synthase Activity by Oltipraz in vitro and in Activated Microglial Cells" 13th International Conference on Cytochrome P450: Biochemistry, Biophysics, and Molecular Biology, Prague, Czech Republic, June 29 – July 3, 2003.

    Goode, W. and Stevens-Truss, R. "Effects of Solvent Composition on the Active Site of Nitric Oxide Synthase". Pew Midstates Science and Mathematics Consortium, Annual Undergraduate Research Symposium in Mathematics and the Physical Sciences, November, 2002..

    Stevens-Truss, R. and Marletta, M. A, and Brownlow, K.  "Calmodulin binds differently to Neuronal and Inducible Nitric Oxide Synthase:  Role of Calcium in the Interactions." 14th Annual Signal Transduction Symposium, May, 2001.

    Stevens-Truss, R., Marletta, M. A., and Brownlow, K.  "Inducible and Neuronal Nitric Oxide Synthase are Differentially Regulated by Calmodulin."  ASBMB Meeting, April, 2001.

    Brownlow, K. and Stevens-Truss, R.  "Activity of Inducible Nitric Oxide Synthase Requires Calcium at Either Site I or site III of Calmodulin."  XX Midwest Enzyme Chemistry Conference, September 2000.



     

     

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